Synthesis of 2,3-dihydroinosine derivatives by reduction using BH3-THF.

K Hirota, R Hattori, H Sajiki, Y Monguchi, O Muraoka, G Tanabe
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Abstract

A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.
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BH3-THF还原合成2,3-二氢肌苷衍生物。
描述了一种新的核苷化学修饰的还原方法。肌苷衍生物与硼四氢呋喃的反应导致嘌呤环的区域选择性还原,得到相应的2,3-二氢肌苷衍生物,产量适中。
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