Defective epidermal utilization and storage of S35 in psoriasis.

Abstract

The problem of the etiology and physiochemical mechanism operative in the development of psoriasis has been a stimulant to the efforts of research workers in the field of dermatology. There has been no dearth of work on the part of dermatologists toward attempting to solve the mystery of this disease. In a 10-year period, from 1948-1957, Sulzberger and Baer 1 and Baer and Whitten 2 summarized 86 investigative studies on psoriasis. The great majority of this work has been directed toward methods of therapy and the study of chemical alterations. A summary of the literature of investigative work on psoriasis is to be found in Shelley and Arthur's review. 3 Recently Flesch and Esoda 4,5 reported their studies of the physical and chemical properties of the scales of psoriasis. They were able to find chemical differences unique enough to propose that these