A preliminary investigation into light-modulated replication of nanobacteria and heart disease.

Andrei P Sommer, Uri Oron, Anne-Marié Pretorius, David S McKay, Neva Ciftcioglu, Adam R Mester, E Olavi Kajander, Harry T Whelan
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引用次数: 16

Abstract

Objective: The purpose of this preliminary study is to evaluate the effect of various wavelengths of light on nanobacteria (NB).

Background data: NB and mitochondria use light for biological processes. NB have been described as multifunctional primordial nanovesicles with the potential to utilize solar energy for replication. NB produce slime, a process common to living bacteria. Slime release is an evolutionary important stress-dependent phenomenon increasing the survival chance of individual bacteria in a colony. In the cardiovascular system, stress-induced bacterial colony formation may lead to a deposition of plaque.

Methods: Cultured NB were irradiated with NASA-LEDs at different wavelengths of light: 670, 728 and 880 nm. Light intensities were about 500k Wm(-2), and energy density was 1 x 10(4) J m(-2).

Results: Monochromatic light clearly affected replication of NB. Maximum replication was achieved at 670 nm.

Conclusions: The results indicate that suitable wavelengths of light could be instrumental in elevating the vitality level of NB, preventing the production of NB-mediated slime, and simultaneously increasing the vitality level of mitochondria. The finding could stimulate the design of cooperative therapy concepts that could reduce death caused by myocardial infarcts.

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纳米细菌的光调制复制与心脏病的初步研究。
目的:初步研究不同波长的光对纳米细菌(nanoobacteria, NB)的影响。背景资料:NB和线粒体利用光进行生物过程。NB被描述为多功能的原始纳米囊泡,具有利用太阳能进行复制的潜力。NB产生黏液,这是活细菌共同的过程。黏液释放是一种重要的进化应激依赖现象,增加了菌落中单个细菌的生存机会。在心血管系统中,应激诱导的细菌菌落形成可导致斑块沉积。方法:用NASA-LEDs在670、728和880 nm不同波长下照射培养的NB。光强约为500k Wm(-2),能量密度为1 × 10(4) jm(-2)。结果:单色光明显影响NB的复制。在670 nm处达到最大复制。结论:适当波长的光可以提高NB的活力水平,阻止NB介导的黏液的产生,同时提高线粒体的活力水平。这一发现可以刺激合作治疗概念的设计,从而减少心肌梗死引起的死亡。
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