The value of urinary sediment examination as a screening method in suspected cases of metachromatic leucodystrophy.

Abstract

Among the various forms of diffuse cerebral sclerosis metachromatic leucodystrophy or leucoencephalopathy has been recognised by certain clinical, biochemical and pathological characteristics [l, 2, 7, 8, 9, 101. The disease has been found to be characterized by a pathologic accumulation of sulphatides (cerebroside sulphuric acid esters). This disease occurs in an infantile, a late infantile and an adult type [5 , 6, 81; the late infantile type is the one most commonly described.