{"title":"The effect of systemic administration of haematin on the tryptophan pyrrolase activity of rat liver","authors":"M.V. Jago, J.F. Nelson, S. Rose","doi":"10.1016/0926-6569(64)90267-6","DOIUrl":null,"url":null,"abstract":"<div><p>The saturation with cofactor of the tryptophan pyrrolase of rat liver was markedly increased by intravenous administration of solutions of haematin. Complete saturation followed the administration of 0.5–1 μmole haematin per 100 g body weight or larger amounts. No significant increase in tryptophan pyrrolase activity accompanied or followed this apparent saturation of the enzyme with cofactor <em>in vivo</em>.</p></div>","PeriodicalId":100170,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects","volume":"92 1","pages":"Pages 44-51"},"PeriodicalIF":0.0000,"publicationDate":"1964-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6569(64)90267-6","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926656964902676","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The saturation with cofactor of the tryptophan pyrrolase of rat liver was markedly increased by intravenous administration of solutions of haematin. Complete saturation followed the administration of 0.5–1 μmole haematin per 100 g body weight or larger amounts. No significant increase in tryptophan pyrrolase activity accompanied or followed this apparent saturation of the enzyme with cofactor in vivo.
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