The inhibition of transport of glucose into human erythrocytes by 2,3,4,6-tetra[O-acethyl]-β-d-glucopyranose

Abstract

$\text{2,3,4,6-}\text{tetra}\text{[O-}\text{acetyl}\text{]-β-}\text{d}\text{-}\text{glucopyranose}$ penetrated into human erythrocytes following a transport mechanism different from that of glucose. However, TAG interacted with the glucose-carrier ssytem, inhibiting the transport of glucose to a variable extent, depending on experimental conditions.

Comparison of the inhibitory effect of TAG on exchange and non-exchange transport showed that it affected a suppression of glucose transport similar to that obtained by lowering the temperature.

The presence of subtances in the matrix of the membrane which regulate the movement of carriers, interacting similarly to TAG, is tentatively suggested.