Studies on glucose-6-phosphatase and glutaminase in rat liver and kidney

Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects Pub Date : 1964-12-23 DOI:10.1016/0926-6569(64)90016-1

R.A. Freedland, A.R. Taylor

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引用次数: 14

Abstract

All treatments which increased liver glucose-6-phosphatase (d-glucose-6-phosphate phosphohydrolase, EC 3.1.3.9) activity also caused an increase in the glucose-6-phosphatase activity of the kidney cortex. Adrenalectomy and hypophysectomy both caused marked decreases in liver and kidney-cortex glucose-6-phosphatase activities. Three treatments increased liver glutaminase (l-glutamine amidohydrolase, EC 3.5.1.2) activity; however, only one of these, a high-protein diet, increased kidney glutaminase activity. Fasting decreased both total available liver glutaminase and kidney glutaminase activities. The removal of the adrenals or pituitary caused large decreases in glutaminase activity in both the liven and cidney. It appears that factors which affected the activity of liver glucose-6-phosphatase activity had a similar effect on kidney-cortex activity. The correlations were more difficult with the glutaminase activity since alterations of glutaminase activity were not noted with as many treatments as affected glucose-6-phosphatase activity.

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大鼠肝脏和肾脏葡萄糖-6-磷酸酶和谷氨酰胺酶的研究

所有提高肝脏葡萄糖-6-磷酸酶(d-葡萄糖-6-磷酸磷酸水解酶，EC 3.1.3.9)活性的处理也引起肾皮质葡萄糖-6-磷酸酶活性的增加。肾上腺切除术和垂体切除术均引起肝、肾皮质葡萄糖-6-磷酸酶活性明显降低。3个处理均提高了肝脏谷氨酰胺酶(l-谷氨酰胺酰胺水解酶，EC 3.5.1.2)活性;然而，只有其中一种，高蛋白饮食，增加肾脏谷氨酰胺酶活性。禁食降低了总有效肝谷氨酰胺酶和肾谷氨酰胺酶活性。肾上腺或垂体的切除导致活肾和肾中谷氨酰胺酶活性的大幅下降。可见，影响肝脏葡萄糖-6-磷酸酶活性的因素对肾皮质活性也有类似的影响。与谷氨酰胺酶活性的相关性更困难，因为谷氨酰胺酶活性的改变在许多处理中都没有被注意到，而葡萄糖-6-磷酸酶活性受到影响。

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