Self-injury behaviour induced by intraplantar carrageenan infiltration: a model of tonic nociception

Brain research. Brain research protocols Pub Date : 2004-04-01 DOI:10.1016/j.brainresprot.2004.01.001

Alberto López-Avila , Gabriela Rodrı́guez-Manzo , Ulises Coffeen , Rosendo del Ángel , Francisco Pellicer

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引用次数: 8

Abstract

The research of chronic nociception using whole animals is an approach plagued with methodological drawbacks within the ethical realm, as well as difficulties in the analysis and interpretation of time dependent results. On this work, we propose an experimental model that displays tonic nociception measured as a quantifiable self-injury behaviour (SIB) produced by the inflammation of soft tissue located in the paw of the rat elicited by carrageenan 1% (CAR) infiltration. We established five categories or levels for the analysis of the self-injury behaviour reflecting the intensity of rat nociception triggered by CAR infiltration. In addition, we determine that this model does not induce inescapable pain by noticing no significant differences when measuring weight gain and sexual behaviour. We propose this nociception model as physiologically and ethically appropriate for the study of long-lasting nociception.

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足底卡拉胶浸润诱导的自伤行为:强直性伤害感觉模型

使用整个动物进行慢性伤害感觉的研究是一种在伦理领域内饱受方法缺陷困扰的方法，以及在分析和解释时间依赖结果方面的困难。在这项工作中，我们提出了一个实验模型，该模型显示了强张性伤害感觉，作为一种可量化的自伤行为(SIB)，这种自伤行为是由1%的卡拉胶(CAR)浸润引起的大鼠爪子软组织炎症所产生的。我们建立了5个类别或水平来分析反映CAR浸润引发的大鼠伤害感受强度的自伤行为。此外，在测量体重增加和性行为时，我们没有注意到明显的差异，从而确定该模型不会引起不可避免的疼痛。我们认为这种伤害感觉模型在生理和伦理上适合于长期伤害感觉的研究。

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Brain research. Brain research protocols

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