Oxidative metabolism of rat blood in the course of alveolar hepatic carcinoma PC-1 growth.

Eksperimental'naia onkologiia Pub Date : 2004-03-01

R M Smolyakova, V I Prokhorova, E A Zhavrid, A A Mashevsky, Yu P Istomin

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Abstract

Aim: To evaluate oxidative metabolism of rat blood in the course of alveolar hepatic cancer growth in vivo.

Methods: The oxidation imbalance was assessed by the rise in the values of the integral index of oxidation stress. The structural and functional state of erythrocyte membranes was investigated by spin electron paramagnetic resonance spectroscopy.

Results: The growth of alveolar carcinoma was found to be associated with intensification of lipid peroxidation processes with increased blood content of conjugated dienes, malonic dialdehyde against the background of decreased concentration of endogenous antioxidants tocopherol and retinol. Destabilization of the structural state of erythrocyte membranes of rat tumor hosts at the development of oxidation stress was studied, which was characterized by nonspecific structural changes of membrane sorption centres, reduction in specific capacity in the protein-lipid contact area and its increase in the phospholipid bilayer, rise in the degree of order and polarity.

Conclusion: Alveolar carcinoma growth in rats resulted in intensification of free radical lipid peroxidation processes with a shift of the prooxidant-antioxidant balance to the left and development of oxidation stress.

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肺泡型肝癌PC-1生长过程中大鼠血液氧化代谢的变化。

目的:探讨大鼠肺泡肝癌生长过程中血液氧化代谢的变化。方法:通过氧化应激积分指数的升高来评价氧化失衡。用自旋电子顺磁共振波谱法研究了红细胞膜的结构和功能状态。结果:肺泡癌的生长与脂质过氧化过程的加剧有关，与内源性抗氧化剂生育酚和视黄醇浓度降低的背景下，血液中共轭二烯、丙二醛含量增加有关。研究了氧化应激发生时大鼠肿瘤宿主红细胞膜结构状态的不稳定，其特征是膜吸收中心的非特异性结构改变，蛋白脂接触区比容量降低，磷脂双分子层比容量增加，有序度和极性升高。结论:大鼠肺泡癌生长导致自由基脂质过氧化过程增强，促氧化-抗氧化平衡左移，氧化应激发生。

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Eksperimental'naia onkologiia

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