Relationship between environmental tobacco smoke and urinary cotinine levels in passive smokers at their residence.

Journal of Exposure Analysis and Environmental Epidemiology Pub Date : 2004-01-01 DOI:10.1038/sj.jea.7500360

Hyojin Kim, Youngwook Lim, Seokju Lee, Soungeun Park, Changsoo Kim, Cheinsoo Hong, Dongchun Shin

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引用次数: 32

Abstract

Studies of the health effects of environmental tobacco smoke (ETS) using measured air concentrations are subject to bias. Cotinine, a nicotine metabolite detected in urine, has been recommended as a quantitative measure of nicotine intake and thus as a marker for ETS exposure in humans. The aim of this study was to correlate home indoor ETS levels with passive smokers' urinary cotinine levels. The urinary cotinine concentrations of 57 non-smoking women who spend >19 h a day at home and the nicotine levels in their living room air were measured over a period of 24 h. Nicotine and urinary cotinine levels were analyzed using GC/MS and HPLC/UV, respectively. In addition, information was collected regarding the smoking habits of the subjects' families. A significant correlation was found between the nicotine levels in indoor air and the urinary cotinine to creatinine ratio of the passive smokers. The smoking habits of the subjects' family members were also correlated to the urinary cotinine levels of the passive smokers.

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被动吸烟者居住地环境吸烟与尿可替宁水平的关系。

使用测量的空气浓度对环境烟草烟雾(ETS)的健康影响进行的研究可能存在偏差。可替宁是一种在尿液中检测到的尼古丁代谢物，已被推荐作为尼古丁摄入量的定量测量方法，从而作为人类接触ETS的标志。本研究的目的是将家庭室内ETS水平与被动吸烟者尿中可替宁水平联系起来。研究人员测量了57名每天在家中度过>19小时的不吸烟女性24小时内的尿可替宁浓度和客厅空气中的尼古丁水平。分别使用GC/MS和HPLC/UV分析了尼古丁和尿可替宁水平。此外，还收集了研究对象家庭吸烟习惯的信息。室内空气中尼古丁含量与被动吸烟者尿可替宁/肌酐比值存在显著相关性。研究对象家庭成员的吸烟习惯也与被动吸烟者尿中可替宁水平相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Exposure Analysis and Environmental Epidemiology

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