Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years

Mitja Letonja , Barbara Guzič-Salobir , Borut Peterlin , Daniel Petrovič
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引用次数: 10

Abstract

The pathogenesis of CAD is similar in man and woman, yet some risk factors have a greater impact on the CAD risk in woman than in man. In this study we assessed the effect of the apoE gene polymorphism on lipid metabolism and risk for CAD in women younger than 65 years (premature CAD). In a cross-sectional case-control study, 147 female Caucasian patients with premature CAD (confirmed by coronarography) were compared with a control group of 114 healthy Caucasian women. The apoE allele frequencies of patients vs. controls were 5.1% vs. 5.7% for ε2, 85.4% vs. 83.3% for ε3, and 9.5% vs. 11% for ε4. The subjects with ε2/3 genotype had statistically significantly higher triglycerides levels than the subjects with ε3/3 genotype (2.23 ± 2.13 mmol⋅L-1 vs. 1.73 ± 0.84 mmol⋅L-1; p<0.05). Logistic regression analysis revealed no association between risk genotypes (ε3/4 and ε4/4) of the apoE gene polymorphism and CAD risk (OR 0.9; 95% CI 0. 5-1.7, P=0.7). We observed metabolic clustering of diabetes mellitus, arterial hypertension, higher BMI and triglycerides, and lower HDL cholesterol in the CAD group compared to the control group. Arterial hypertension, diabetes, HDL cholesterol level, and BMI were independent risk factors for premature CAD in female population, whereas, the risk genotype of the apoE gene polymorphism was not. In conclusion, in Slovene women risk genotypes of the apoE gene polymorphism are not associated with premature CAD; a metabolic clustering of diabetes, HDL, triglycerides and arterial hypertension is frequently present in Caucasian women with premature CAD.

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载脂蛋白E基因多态性影响甘油三酯,但不影响65岁以下高加索女性的CAD风险
CAD的发病机制男女相似,但一些危险因素对女性的影响大于男性。在这项研究中,我们评估了载脂蛋白e基因多态性对65岁以下女性脂质代谢和冠心病风险的影响(过早冠心病)。在一项横断面病例对照研究中,147名女性白种人早发CAD患者(经冠状造影确诊)与114名健康白种人女性的对照组进行了比较。患者与对照组的apoE等位基因频率分别为ε2 5.1% vs 5.7%、ε3 85.4% vs 83.3%、ε4 9.5% vs 11%。ε2/3基因型组甘油三酯水平显著高于ε3/3基因型组(2.23±2.13 mmol·L-1∶1.73±0.84 mmol·L-1);术中,0.05)。Logistic回归分析显示,apoE基因多态性风险基因型(ε3/4和ε4/4)与冠心病风险无相关性(OR 0.9;95% ci 0。5 - 1.7, P = 0.7)。我们观察到,与对照组相比,冠心病组有糖尿病、动脉高血压、BMI和甘油三酯升高、高密度脂蛋白胆固醇降低的代谢聚类。动脉高血压、糖尿病、高密度脂蛋白胆固醇水平和身体质量指数是女性人群早发CAD的独立危险因素,而apoE基因多态性的风险基因型不存在。总之,在斯洛文尼亚妇女中,apoE基因多态性的风险基因型与早期CAD无关;糖尿病、高密度脂蛋白、甘油三酯和动脉高血压的代谢性聚类在早发冠心病的高加索女性中经常出现。
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