[Initial experience of proton beam therapy at the new facility of the University of Tsukuba].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica Pub Date : 2004-05-01

Kenji Kagei, Koichi Tokuuye, Shinji Sugahara, Masaharu Hata, Hiroshi Igaki, Takayuki Hashimoto, Kiyoshi Ohara, Yasuyuki Akine

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Abstract

Purpose: To present the initial experience with proton beam therapy at the new Proton Medical Research Center (PMRC) of the University of Tsukuba.

Materials and methods: The new facility has a synchrotron with maximum energy of 250MeV and two rotational gantries. We treated 105 patients with 120 lesions with proton beams in the first year, beginning in September 2001. The most common lesion treated was primary liver cancer (40 lesions) followed by lung cancer, head and neck cancers, and prostate cancer. Concurrent X-ray radiotherapy was given for 38 of the 120 lesions.

Results: The median follow-up period was 11 months (range, 1-19 months). Of the 105 patients, 97% had Grade 0-2 RTOG/EORTC acute morbidities, while the remaining 3% had Grade 3. Tumor response after irradiation was CR for 35% of the lesions, PR for 25%, SD for 22%, PD for 9%, and not evaluated for 9%.

Conclusion: The proton beam therapy conducted at the new facility of the University of Tsukuba was safe and effective.

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[在筑波大学新设施的质子束治疗的初步经验]。

目的:介绍筑波大学新质子医学研究中心(PMRC)质子束治疗的初步经验。材料和方法:新设施有一个最大能量为250MeV的同步加速器和两个旋转龙门。从2001年9月开始，我们在第一年用质子束治疗了105名患者，120个病变。最常见的病变是原发性肝癌(40个病变)，其次是肺癌、头颈癌和前列腺癌。120个病灶中的38个同时接受x线放疗。结果:中位随访时间为11个月(范围1-19个月)。105例患者中，97%为0-2级RTOG/EORTC急性发病率，其余3%为3级。放疗后的肿瘤反应为:35%的病灶CR, 25% PR, 22% SD, 9% PD, 9%未评估。结论:在筑波大学新设施进行的质子束治疗安全有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica

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