Mitochondrial alterations in muscle biopsies of patients on statin therapy.

S Gambelli, M T Dotti, A Malandrini, M Mondelli, M L Stromillo, C Gaudiano, A Federico
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Abstract

Clinical and biopsy study of nine patients on statin therapy suffering from various myopathic syndromes is reported. Biopsy findings showed non specific myopathic signs and mitochondrial changes, such as subsarcolemmal accumulation, morphological alterations, lipid increase and Cox-negative fibers. These findings confirm that statins may cause muscle damage and impair oxidative metabolism.

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他汀类药物治疗患者肌肉活检的线粒体改变。
本文报道了9例接受他汀类药物治疗的各种肌病综合征患者的临床和活检研究。活检结果显示非特异性肌病征象和线粒体改变,如肌层下积聚、形态改变、脂质增加和cox阴性纤维。这些发现证实了他汀类药物可能导致肌肉损伤并损害氧化代谢。
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