Expression of matrix metalloproteinase 9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection.

Journal of Zhejiang University. Science Pub Date : 2004-10-01 DOI:10.1631/jzus.2004.1304

Jian-Guo Tang, Xuan Li, Ping Chen

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引用次数: 7

Abstract

Objective: To evaluate the expression of matrix metalloproteinase-9 (MMP9) in nasopharyngeal carcinoma and the association between MMP9 and Epstein-Barr virus infection.

Methods: The MMP9 expression was studied by immunohistochemical analysis; and Epstein-Barr virus encoded small nuclear mRNA-1 (EBER-1) produced by in situ hybridization were examined in 41 nasopharyngeal carcinoma sections, and the relation between them, and the associations of MMP9 with clinical features were statistically analyzed.

Results: Positive expression rate of MMP9 was 73.17%. The expression of MMP9 showed significant positive correlation with the expression of EBER-1 (gamma=0.483, P=0.001). There was significant association of MMP9 expression with lymph nodes metastasis and clinical stage (P<0.001), non-significant association with age, gender, pathological classification and T classification.

Conclusions: The highly pronounced expression of MMP9 is associated with cervical lymph nodes metastasis. Epstein-Barr virus can enhance NPC metastasis by up-regulating the expression of MMP9.

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基质金属蛋白酶9在鼻咽癌组织中的表达及其与eb病毒感染的关系

目的:探讨基质金属蛋白酶9 (matrix metalloproteinase-9, MMP9)在鼻咽癌组织中的表达及其与eb病毒感染的关系。方法:采用免疫组化方法研究MMP9的表达;采用原位杂交法检测41例鼻咽癌切片中Epstein-Barr病毒编码的小核mRNA-1 (EBER-1)的表达，并分析两者之间的关系以及MMP9与临床特征的相关性。结果:MMP9阳性表达率为73.17%。MMP9表达与EBER-1表达呈显著正相关(gamma=0.483, P=0.001)。结论:MMP9的高表达与颈淋巴结转移及临床分期相关。Epstein-Barr病毒通过上调MMP9的表达促进鼻咽癌转移。

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Journal of Zhejiang University. Science

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