Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation.

C Lelliott, A J Vidal-Puig
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引用次数: 193

Abstract

Obesity and type 2 diabetes mellitus are the major noncommunicable public health problem of the 21st century. The best strategy to tackle this problem is to develop strategies to prevent/treat obesity. However, it is becoming clear that despite successful research identifying weight regulatory pathways, the development of the obesity epidemic is outpacing scientific progress. The lack of success controlling the obesity epidemic in an aging population will result in another subsequent uncontrolled epidemic of complications. Our research focuses on the mechanisms causing lipotoxicity aiming to identify suitable strategies to prevent or at least retard the development of the metabolic syndrome. Previous work using transgenic and knockout mouse models has shown an interplay between white adipose tissue and skeletal muscle linking fatty acid (FA) synthesis with reciprocal effects on FA oxidation. Work from our lab and others suggests that defective adipose tissue is a key link between obesity, insulin resistance and type 2 diabetes mellitus by promoting the development of lipotoxicity in peripheral tissues. We propose a series of models to describe the process by which the adipose tissue could react to an energy-rich environment and responds depending on genetic and physiological factors, impacting on the functions of other peripheral tissues. We suggest that by examining hypotheses that encompass multiple organs and the partitioning of energy between these organs, a suitable strategy can be devised for the treatment of chronic obesity.

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脂肪中毒,脂肪生成和脂肪酸氧化之间的不平衡。
肥胖和2型糖尿病是21世纪主要的非传染性公共卫生问题。解决这个问题的最佳策略是制定预防/治疗肥胖的策略。然而,越来越清楚的是,尽管成功的研究确定了体重调节途径,但肥胖流行病的发展速度超过了科学进步。在老龄人口中肥胖症流行控制的不成功将导致并发症的另一个后续不受控制的流行。我们的研究重点是引起脂肪毒性的机制,旨在确定适当的策略来预防或至少延缓代谢综合征的发展。先前使用转基因和敲除小鼠模型的研究表明,白色脂肪组织和骨骼肌之间存在相互作用,将脂肪酸(FA)合成与FA氧化的相互作用联系起来。我们的实验室和其他人的研究表明,脂肪组织缺陷是肥胖、胰岛素抵抗和2型糖尿病之间的关键联系,它促进了外周组织脂肪毒性的发展。我们提出了一系列模型来描述脂肪组织对能量丰富的环境做出反应的过程,并根据遗传和生理因素做出反应,影响其他周围组织的功能。我们建议,通过检查包含多个器官和这些器官之间的能量分配的假设,可以设计出治疗慢性肥胖的合适策略。
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