Valpha14 NKT cell-mediated anti-tumor responses and their clinical application.

Springer seminars in immunopathology Pub Date : 2005-06-01 Epub Date: 2005-01-14 DOI:10.1007/s00281-004-0194-y
Ken-Ichiro Seino, Shin-Ichiro Fujii, Michishige Harada, Shinichiro Motohashi, Toshinori Nakayama, Takehiko Fujisawa, Masaru Taniguchi
{"title":"Valpha14 NKT cell-mediated anti-tumor responses and their clinical application.","authors":"Ken-Ichiro Seino,&nbsp;Shin-Ichiro Fujii,&nbsp;Michishige Harada,&nbsp;Shinichiro Motohashi,&nbsp;Toshinori Nakayama,&nbsp;Takehiko Fujisawa,&nbsp;Masaru Taniguchi","doi":"10.1007/s00281-004-0194-y","DOIUrl":null,"url":null,"abstract":"<p><p>A unique lymphocyte population, Valpha14 NKT cells, has recently been revealed to be a key player in the immune responses against tumors. Activation of Valpha14 NKT cells affects various cell types, particularly dendritic cells (DCs), NK cells, CD4 Th1 cells, and CD8 cytotoxic T cells in the innate and acquired immune systems, eventually resulting in the enhanced activation of NKT cell-mediated cellular cascade in the anti-tumor responses. The specific ligand, alpha-galactosylceramide (alpha-GalCer), effectively stimulates mouse and human NKT cells, making NKT cells an ideal target for the development of cancer immunotherapy. Clinical trials using alpha-GalCer have actually started in several centers in the world. In this review, we summarize the Valpha14 NKT cell-mediated cellular cascade in the anti-tumor response in mice and discuss potential clinical applications of alpha-GalCer-pulsed DC therapy.</p>","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":" ","pages":"65-74"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-004-0194-y","citationCount":"21","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Springer seminars in immunopathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00281-004-0194-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2005/1/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 21

Abstract

A unique lymphocyte population, Valpha14 NKT cells, has recently been revealed to be a key player in the immune responses against tumors. Activation of Valpha14 NKT cells affects various cell types, particularly dendritic cells (DCs), NK cells, CD4 Th1 cells, and CD8 cytotoxic T cells in the innate and acquired immune systems, eventually resulting in the enhanced activation of NKT cell-mediated cellular cascade in the anti-tumor responses. The specific ligand, alpha-galactosylceramide (alpha-GalCer), effectively stimulates mouse and human NKT cells, making NKT cells an ideal target for the development of cancer immunotherapy. Clinical trials using alpha-GalCer have actually started in several centers in the world. In this review, we summarize the Valpha14 NKT cell-mediated cellular cascade in the anti-tumor response in mice and discuss potential clinical applications of alpha-GalCer-pulsed DC therapy.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Valpha14 NKT细胞介导的抗肿瘤反应及其临床应用
一种独特的淋巴细胞群,Valpha14 NKT细胞,最近被发现在对抗肿瘤的免疫反应中起关键作用。Valpha14 NKT细胞的激活影响各种细胞类型,特别是先天和获得性免疫系统中的树突状细胞(dc)、NK细胞、CD4 Th1细胞和CD8细胞毒性T细胞,最终导致NKT细胞介导的细胞级联在抗肿瘤反应中的激活增强。特异性配体α -半乳糖神经酰胺(α - galcer)可有效刺激小鼠和人类NKT细胞,使NKT细胞成为开发癌症免疫疗法的理想靶点。使用α - galcer的临床试验已经在世界上的几个中心开始了。在这篇综述中,我们总结了Valpha14 NKT细胞介导的细胞级联在小鼠抗肿瘤反应中的作用,并讨论了α - galser脉冲DC治疗的潜在临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The discovery of immunostimulatory DNA sequence Cellular aspects of vasculitis — T cell-mediated aspects The complex role of Fcgamma receptors in the pathology of arthritis. IgA and IgA-specific receptors in human disease: structural and functional insights into pathogenesis and therapeutic potential. IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1