Role of anti-β-glucan antibody in host defense against fungi

FEMS immunology and medical microbiology Pub Date : 2005-04-01 DOI:10.1016/j.femsim.2004.12.012

Ken-ichi Ishibashi , Masaharu Yoshida , Iwao Nakabayashi , Hiroyasu Shinohara , Noriko N. Miura , Yoshiyuki Adachi , Naohito Ohno

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引用次数: 46

Abstract

We have recently detected an anti-β-glucan antibody in normal human and normal mouse sera. The anti-β-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-β-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-β-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall β-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-β-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-β-glucan antibody formed an antigen–antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi.

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抗β-葡聚糖抗体在宿主抗真菌中的作用

我们最近在正常人和正常小鼠血清中检测到一种抗β-葡聚糖抗体。抗β-葡聚糖抗体对致病性真菌曲霉和念珠菌细胞壁葡聚糖具有反应性。抗β-葡聚糖抗体能结合整个念珠菌细胞。体外培养的巨噬细胞也能增强其杀灭念珠菌活性。静脉给药念珠菌或曲霉菌溶解细胞壁β-葡聚糖的DBA/2小鼠抗β-葡聚糖抗体滴度随剂量显著降低。此外，在深部真菌病患者中，抗β-葡聚糖抗体滴度下降，这种变化与临床症状和c反应蛋白等参数相关。提示抗β-葡聚糖抗体形成抗原-抗体复合物，作为识别病原真菌的分子参与免疫应答。

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来源期刊

FEMS immunology and medical microbiology 医学-传染病学

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3-8 weeks