Traumatic axolemmal and cytoskeletal derangement in myelinated axons of human oedematous cerebral cortex and loss of consciousness. An electron microscopic study using cortical biopsies.

Abstract

Cortical biopsies of 7 patients with clinical diagnosis of severe head trauma and complicated brain trauma with subdural and epidural hematoma, and loss of consciousness were examined with the transmission electron microscope to study axolemmal and cytoskeletal damage in myelinated axons. Granular disintegration of microtubules and misaligned and fragmented neurofilaments, and fragmentation of axolemmal membrane were observed in most patients studied. In some cases a differential response characterized by increased number of neurofilaments and decreased number or disappearance of microtubules was found. In few cases apparently intact microtubules coexisting with fragmented ones were found. These findings are discussed in relation with traumatic brain edema and associated anoxic-ischemic conditions, the Hameroff-Penrose hypothesis relating microtubules and consciousness, and the existing and contemporary knowledge on neural correlates of consciousness.