Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

Farmaco (Societa chimica italiana : 1989) Pub Date : 2005-08-01 DOI:10.1016/j.farmac.2005.05.004

André L. Santos, Regina M. Takeuchi, Marcela P. Mariotti, Marcelo F. De Oliveira, Maria V.B. Zanoni, Nelson R. Stradiotto

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引用次数: 18

Abstract

In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E_1/2 = 0.99 V vs. Ag/AgCl_sat, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51 ± 0.07) × 10^–5 cm s^–1, with a αn_a value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 × 10^–5 to 1.0 × 10^–2 mol l^–1 range, being obtained a detection limit of 2.4 × 10^–5 mol l^–1. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.

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玻碳旋转圆盘电极电化学氧化测定阿苯达唑的研究

本文采用玻碳旋转圆盘电极对阿苯达唑(ABZ)进行了电化学氧化。本文还提出了利用线性扫描伏安法定量药物制剂中ABZ的电分析方法。在E1/2 = 0.99 V条件下，ABZ与Ag/AgClsat发生了电化学氧化。得到的动力学参数表明，ABZ氧化过程的标准非均相速率常数为(1.51±0.07)× 10-5 cm s-1， αna值为0.76。ABZ浓度与限流关系在5.0 × 10-5 ~ 1.0 × 10-2 mol - 1范围内呈线性关系，检出限为2.4 × 10-5 mol - 1。该方法已应用于制剂中ABZ的定量分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Farmaco (Societa chimica italiana : 1989)

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