Emmanuella Di Scala, Ian Findlay, Stephanie Rose, Michel Aupart, Jorge Argibay, Pierre Cosnay, Veronique Bozon
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引用次数: 5
Abstract
In human atrial myocytes, serotonin rather than sympathetic, stimulation is more frequently associated with atrial fibrillation. So does the arrhythmogenic effect of serotonin result from the mechanism of action of the receptor or the context of its action upon cardiac myocytes? The capacity of agonists to produce cAMP followed the sequence 5-HT < Iso < Forskolin to increase ICaL with 5-HT = Iso = Forskolin. The simultaneous application of threshold concentrations of 5-HT and Iso maximally increased ICaL. We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL.
在人心房肌细胞中，血清素比交感神经刺激更常与心房颤动相关。那么，血清素的致心律失常作用是由受体的作用机制还是其作用于心肌细胞的环境引起的呢?激动剂产生cAMP的能力顺序为5-HT < Iso < Forskolin，以5-HT = Iso = Forskolin增加ICaL。同时应用5-羟色胺和Iso的阈值浓度最大限度地增加了ICaL。我们将证明5-HT对人心房肌细胞的影响是cAMP低生成和ICaL最大激活之间的不平衡。
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