Tetanus immunisation policy in England and Wales--an overview of the literature.

S Bracebridge, N Crowcroft, J White
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Abstract

Current UK policy on immunisation for tetanus has changed in the light of evidence that five doses of vaccine probably provides sufficient protection as long as high-risk wounds are managed with tetanus immunoglobulin. This paper reviews the evidence base for tetanus immunisation policy in England and Wales: the epidemiology of tetanus, vaccination coverage and response to tetanus toxoid, and population immunity to tetanus. The paper highlights gaps in our current knowledge of tetanus vaccination and policy implementation, and makes recommendations for further investigations.

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英格兰和威尔士破伤风免疫政策——文献综述。
目前英国关于破伤风免疫接种的政策已经改变,因为有证据表明,只要用破伤风免疫球蛋白处理高风险伤口,五剂疫苗可能就能提供足够的保护。本文综述了英格兰和威尔士破伤风免疫政策的证据基础:破伤风流行病学,疫苗接种覆盖率和对破伤风类毒素的反应,以及人口对破伤风的免疫力。这篇论文强调了我们目前在破伤风疫苗接种和政策实施方面的知识差距,并提出了进一步调查的建议。
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