The role of the Lumina intense pulsed light system in the treatment of port wine stains—a case controlled study

N. Reynolds, J. Exley, S. Hills, S. Falder, C. Duff, J. Kenealy
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引用次数: 43

Abstract

The pulsed dye laser has been the treatment of choice for port wine stains over the past 20 years.

In the past 5 years there has been increasing discussion of the role of other light treatments, such as the intense pulsed light system in the treatment of port wine stains. These systems use high-energy lamps, which emit noncoherent broad-spectrum light. Cut off filters are applied depending on the treatment modality to limit the wavelengths emitted.

We present the results of a 3-year prospective within patient controlled clinical trial using an intense pulsed light system called the Lumina, developed by Lynton Lasers of Cheshire, England.

Our aims and objectives were to assess the effectiveness of the system in the treatment of port wine stains in a human model and to record the optimum treatment parameters and the incidence of side effects.

Following ethical approval 12 subjects were enrolled into the trial. In order to meet the requirements of the local ethics committee these were all adults with port wine stains located in less visible areas of the body.

The results showed that eight of the 12 subjects had some degree of fading of their port wine stain as measured on a percentage scoring system. Of the four who failed to show any response, all had pink port wine stains. It did seem the case that the darker the port wine stain, the better the fading seen. Furthermore, the more distal lesions tended to be less responsive than those situated closer to the head area. However, it is difficult to draw any definitive statistical conclusions due to the small number of patients in the trial.

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Lumina强脉冲光系统在处理波特酒染色中的作用——一项病例对照研究
在过去的20年里,脉冲染料激光一直是治疗葡萄酒色斑的首选。在过去的5年里,人们越来越多地讨论其他光处理的作用,比如强脉冲光系统在处理葡萄酒污渍方面的作用。这些系统使用高能量的灯,发出非相干的广谱光。根据处理方式应用截止滤光片来限制发射的波长。我们介绍了一项为期3年的前瞻性患者对照临床试验的结果,该试验使用了一种名为Lumina的强脉冲光系统,由英国柴郡的林顿激光公司开发。我们的目的和目标是评估该系统在人体模型中治疗波特酒污渍的有效性,并记录最佳治疗参数和副作用的发生率。在伦理批准后,12名受试者被纳入试验。为了满足当地伦理委员会的要求,这些人都是成年人,身上不太显眼的地方有葡萄酒污渍。结果显示,12名受试者中有8名在百分比评分系统中有一定程度的葡萄酒污渍褪色。在没有任何反应的四个人中,所有人都有粉红色的葡萄酒污渍。看起来确实是这样,葡萄酒的颜色越深,褪色的效果越明显。此外,远端病变往往比靠近头部区域的病变反应更差。然而,由于试验中患者数量较少,很难得出任何明确的统计结论。
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