Host defense effector molecules in mucosal secretions

FEMS immunology and medical microbiology Pub Date : 2005-08-01 DOI:10.1016/j.femsim.2005.03.004

G. Sandra Tjabringa , Joost B. Vos , Diana Olthuis , Dennis K. Ninaber , Klaus F. Rabe , Joost Schalkwijk , Pieter S. Hiemstra , Patrick L.J.M. Zeeuwen

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引用次数: 54

Abstract

Mucosal secretions contain a range of defense effector molecules including antimicrobial peptides and proteinase inhibitors. These molecules play a central role in host defense against infection, and in a variety of immune and inflammatory reactions. The aim of this study was to analyze the levels of neutrophil defensins, the cathelicidin hCAP-18/LL-37, and the proteinase inhibitors secretory leukocyte proteinase inhibitor, SKALP/elafin and cystatin M/E in various mucosal secretions and urine. We show here that especially seminal plasma is characterized by high concentrations of hCAP-18/LL-37, SLPI, SKALP/elafin and cystatin M/E. The results of this study demonstrate that each mucosal secretion is characterized by a unique profile of effector molecules, which may supply individual mucosal secretions with specific properties related to the control of local infection and inflammation.

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粘膜分泌物中的宿主防御效应分子

粘膜分泌物含有一系列防御效应分子，包括抗菌肽和蛋白酶抑制剂。这些分子在宿主防御感染以及各种免疫和炎症反应中起着核心作用。本研究的目的是分析各种粘膜分泌物和尿液中中性粒细胞防御素、抗菌肽hCAP-18/LL-37、蛋白酶抑制剂、白细胞蛋白酶抑制剂SKALP/elafin和胱抑素M/E的水平。我们在这里表明，特别是精浆具有高浓度的hCAP-18/LL-37、SLPI、SKALP/elafin和胱抑素M/E。本研究结果表明，每种粘膜分泌物都具有独特的效应分子特征，这些效应分子可能为个体粘膜分泌物提供与局部感染和炎症控制相关的特定特性。

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来源期刊

FEMS immunology and medical microbiology 医学-传染病学

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审稿时长

3-8 weeks