{"title":"“Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry”","authors":"Tarek Wahdan, Nadia Abd El-Ghany","doi":"10.1016/j.farmac.2005.07.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>A differential pulse voltammetric method was described for the determination of domperidone. The method was based on the anodic oxidation of domperidone on a glassy carbon electrode at +0.64 V vs. SCE in Britton–Robinson buffer solution of pH 2.3. The reversibility of the oxidation was tested by cyclic voltammetry; the electrode process is irreversible and diffusion–adsorption controlled. Calibrations are linear over the range 1.0</span> <!-->×<!--> <!-->10<sup>–6</sup>–2.0<!--> <!-->×<!--> <!-->10<sup>–5</sup> M of domperidone with a detection limit of 4.0<!--> <!-->×<!--> <!-->10<sup>–7</sup> M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.</p></div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 10","pages":"Pages 830-833"},"PeriodicalIF":0.0000,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.07.001","citationCount":"33","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05001539","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 33
Abstract
A differential pulse voltammetric method was described for the determination of domperidone. The method was based on the anodic oxidation of domperidone on a glassy carbon electrode at +0.64 V vs. SCE in Britton–Robinson buffer solution of pH 2.3. The reversibility of the oxidation was tested by cyclic voltammetry; the electrode process is irreversible and diffusion–adsorption controlled. Calibrations are linear over the range 1.0 × 10–6–2.0 × 10–5 M of domperidone with a detection limit of 4.0 × 10–7 M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.
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