Toxicology studies of CIMSTAR 3800 in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of CIMSTAR 3800 in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies).

Abstract

CIMSTAR 3800 is a metalworking fluid used as a lubricant and coolant liquid on the surface of the worked piece to remove heat and fine swarf and to provide corrosion inhibition at the newly cut surface. CIMSTAR 3800 is used in the general machining and grinding of automotive aluminum parts and on light to moderate machining and grinding of light steel, stainless steels, hardened steels, and other materials. CIMSTAR 3800 was nominated by the National Institute for Occupational Safety and Health for study by the National Toxicology Program because of its high production volume, the large number of occupationally exposed workers, the lack of carcinogenicity and chronic toxicology data, and because epidemiologic data indicate an increased incidence of laryngeal cancer in workers exposed to metalworking fluids. Male and female F344/NTac rats and B6C3F1/N mice were exposed to CIMSTAR 3800 by inhalation for 3 months, and male and female Wistar Han [Crl:WI (Han)] rats (referred to as Wistar Han rats) and B6C3F1/N mice were exposed to CIMSTAR 3800 by inhalation for 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichia coli, and rat and mouse peripheral blood erythrocytes. (Abstract Abridged).