Ali Bani-Fatemi, Christopher Adanty, Nasia Dai, Ariel Graff, Philip Gerretsen, Vincenzo De Luca
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引用次数: 1
Abstract
Background: Studies have shown that the overall copy number variant (CNV) load is associated with schizophrenia. Schizophrenia is a mental disorder that is frequently associated with suicidal behavior.
Methods: We recruited 263 patients with schizophrenia from the Centre for Addiction and Mental Health. The Columbia Suicide Severity Rating Scale was used to assess the presence of lifetime suicide attempt. Genotyping was completed using the Illumina Omni 2.5 chip. We tested the association between deletion events on chromosome 22 with suicide attempt in our schizophrenia sample.
Results: There was no significant difference between suicide attempters and non-attempters considering the presence/absence of deletion events on chromosome 22.
Conclusion: Although our results did not show a significant association between deletions on chromosome 22 and suicide attempt in schizophrenia, CNV studies may reveal important, novel insights and open further investigation for the treatment of neuropsychiatric diseases.
背景:研究表明，总拷贝数变异(CNV)负荷与精神分裂症有关。精神分裂症是一种精神障碍，通常与自杀行为有关。方法:我们从成瘾和心理健康中心招募了263名精神分裂症患者。使用哥伦比亚自杀严重程度评定量表评估终生自杀企图的存在。采用Illumina Omni 2.5芯片完成基因分型。我们在我们的精神分裂症样本中测试了22号染色体缺失事件与自杀企图之间的关系。结果:考虑到22号染色体缺失事件的存在与否，自杀未遂者和非自杀未遂者之间没有显著差异。结论:虽然我们的研究结果没有显示22号染色体缺失与精神分裂症患者自杀企图之间的显著关联，但CNV研究可能为神经精神疾病的治疗提供了重要的、新颖的见解，并为进一步的研究开辟了道路。
期刊介绍：
The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.
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