Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2021-12-01 DOI:10.1080/13510002.2021.1891808
Javier Toro-Pérez, Ramón Rodrigo
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Abstract

Background: The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress could be an unavoidable effect derived even from the surgical procedure itself.

Methods: A systematic review was performed following an electronic search of Pubmed and ScienceDirect databases. Keywords such as sepsis, oxidative stress, organ dysfunction, antioxidants, outcomes in postoperative complications, among others, were used. Review articles were preferably used between the years 2015 onwards, not excluding older ones.

Results: The vast majority point to the role of oxidative stress in generating greater damage and worse prognosis in postoperative patients without the necessary care and precautions, taking importance on the use of antioxidants to prevent this problem.

Discussions: Oxidative stress represents a common final pathway related to pathological processes such as inflammation or ischemia-reperfusion, among others. The expression of greater severity of these complications can result in multiple organ dysfunction or sepsis. The aim of this study was to present an update of the role of oxidative stress on surgical postoperative complications.

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氧化应激在术后并发症和多器官功能障碍综合征机制中的作用。
背景:多年来,人们一直在研究手术后的损伤程度。许多手术并发症会影响患者术后的生活质量,甚至导致死亡。虽然这些并发症通常是由多因素机制造成的,但氧化应激在病理生理学中起着关键作用。此外,氧化应激甚至可能是手术过程本身产生的不可避免的影响:方法:通过对 Pubmed 和 ScienceDirect 数据库的电子检索,进行了系统性综述。关键词包括脓毒症、氧化应激、器官功能障碍、抗氧化剂、术后并发症的结果等。回顾性文章最好使用2015年以后的文章,不排除更早的文章:结果:绝大多数文章都指出氧化应激在术后患者未采取必要护理和预防措施的情况下造成更大损害和更差预后的作用,并重视使用抗氧化剂来预防这一问题:氧化应激是与炎症或缺血再灌注等病理过程相关的常见最终途径。这些并发症的严重程度可导致多器官功能障碍或败血症。本研究旨在介绍氧化应激对手术术后并发症的最新作用。
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来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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