Efficacy of Electrical Spinal Cord Stimulation with Neuromodulating Medications: A Systematic Review.

Q3 Medicine Psychopharmacology bulletin Pub Date : 2020-10-15

Weston Case Nadherny, Kenneth Fiala, Ivan Urits, Omar Viswanath, Alaa Abd-Elsayed

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Abstract

Background: Chronic pain is a prevalent and debilitating problem for millions of people and spinal cord stimulation (SCS) is one option for treatment. It has been shown to have membrane stabilizing properties and is often used in conjunction with medications that are also believed to offer pain control through membrane stabilization.

Objective: The goal of this review is to analyze the effects of SCS combined with medications to evaluate for augmentative therapeutic effect.

Setting: Systematic review.

Methods: A systematic computerized search of the literature was conducted using PubMed, the Cochrane Library, and EMBASE for articles published in English.

Results: We report three articles that discuss the potential for augmentative effects of medication in combination with SCS. Located articles related primarily to SCS combined with Gabapentin, TCA, or SNRI.

Limitations: The limited number of articles reflects a need for more investigation in this area.

Conclusion: Based on the suspected mechanisms for SCS and neuromodulating medications, there is reason to believe adding these medical therapies may enhance the effects of SCS.

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神经调节药物对脊髓电刺激的疗效:一项系统综述。

背景:慢性疼痛是数百万人普遍存在的问题，脊髓刺激(SCS)是治疗的一种选择。它已被证明具有膜稳定特性，并且经常与药物一起使用，这些药物也被认为可以通过膜稳定来控制疼痛。目的:本综述的目的是分析SCS联合药物治疗的效果，以评价其增强治疗效果。设置:系统评价。方法:使用PubMed、Cochrane图书馆和EMBASE对已发表的英文文章进行系统的计算机检索。结果:我们报告了三篇文章，讨论了药物联合SCS的潜在增强作用。定位主要与SCS联合加巴喷丁、TCA或SNRI相关的文章。局限性:有限的文章数量反映了在这个领域需要更多的调查。结论:基于对SCS和神经调节药物作用机制的推测，我们有理由相信加入这些药物治疗可以增强SCS的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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