Continental Origin for Q Haplogroup Patrilineages in Argentina and Paraguay.

4区生物学 Q2 Medicine Human Biology Pub Date : 2021-02-01 DOI:10.13110/humanbiology.92.2.01

Laura S Jurado Medina, Paula B Paz Sepúlveda, Virginia Ramallo, Camila Sala, Julieta Beltramo, Marisol Schwab, Josefina M B Motti, María Rita Santos, Mariela V Cuello, Susana Salceda, José E Dipierri, Emma L Alfaro Gómez, Marina Muzzio, Claudio M Bravi, Graciela Bailliet

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引用次数: 5

Abstract

Haplogroup Q originated in Eurasia around 30,000 years ago. It is present in Y-chromosomes from Asia and Europe at rather low frequencies. Since America is undoubtedly one of the continents where this haplogroup is highly represented, it has been defined as one of the founding haplogroups. Its M3 clade has been early described as the most frequent, with pan-American representation. However, it was also possible to find several other haplogroup Q clades at low frequencies. Numerous mutations have been described for haplogroup Q, allowing analysis of its variability and assignment of its geographic origin. We have analyzed 442 samples of unrelated men from Argentina and Paraguay belonging to haplogroup Q; here we report specifically on 27 Q (xM3) lineages. We tested 3 single-nucleotide polymorphisms (SNPs) by amplified product-length polymorphism (APLP) analysis, 3 SNPs for restriction fragment length polymorphism (RFLP) analysis, 15 SNPs by Sanger sequencing, and 17 short tandem repeats (STRs). Our approach allowed us to identify five subhaplogroups. Q-M3 and Q-CTS2730/Z780 are undoubtedly autochthonous lineages and represent the most frequent subhaplogroups, with significant representation in self-defined aboriginal populations, and their autochthonous status has been previously described. The aim of present work was to identify the continental origin of the remaining Q lineages. Thus, we analyzed the STR haplotypes for the samples and compared them with haplotypes described by other authors for the rest of the world. Even when haplogroup Q lineages have been extensively studied in America, some of them could have their origin in post-Columbian human migration from Europe and Middle East.

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阿根廷和巴拉圭Q单倍群父系的大陆起源。

单倍群Q起源于大约3万年前的欧亚大陆。它在亚洲和欧洲的y染色体中以相当低的频率存在。由于美洲无疑是这种单倍群最具代表性的大陆之一，因此它被定义为创始单倍群之一。它的M3分支早先被描述为最常见的，具有泛美代表性。然而，也有可能在低频率上发现其他几个单倍群Q分支。单倍群Q的许多突变被描述，允许分析其变异性和分配其地理起源。我们分析了442个来自阿根廷和巴拉圭的无血缘关系的Q单倍群男性样本;这里我们专门报道27个Q (xM3)谱系。通过扩增产物长度多态性(APLP)分析检测了3个单核苷酸多态性(snp)，限制性片段长度多态性(RFLP)分析检测了3个snp, Sanger测序检测了15个snp，以及17个短串联重复序列(STRs)。我们的方法使我们确定了五个亚单倍群。Q-M3和Q-CTS2730/Z780无疑是本土谱系，代表了最常见的亚单倍群，在自定义的土著人群中具有重要的代表性，其本土地位先前已被描述。目前工作的目的是确定剩余Q血统的大陆起源。因此，我们分析了样本的STR单倍型，并将其与其他作者描述的世界其他地区的单倍型进行了比较。即使在美国对单倍群Q谱系进行了广泛的研究，其中一些人的起源可能是哥伦布发现新大陆后从欧洲和中东迁徙而来的人类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Biology 生物-生物学

CiteScore

1.90

自引率

0.00%

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审稿时长

>12 weeks

期刊介绍： Human Biology publishes original scientific articles, brief communications, letters to the editor, and review articles on the general topic of biological anthropology. Our main focus is understanding human biological variation and human evolution through a broad range of approaches. We encourage investigators to submit any study on human biological diversity presented from an evolutionary or adaptive perspective. Priority will be given to interdisciplinary studies that seek to better explain the interaction between cultural processes and biological processes in our evolution. Methodological papers are also encouraged. Any computational approach intended to summarize cultural variation is encouraged. Studies that are essentially descriptive or concern only a limited geographic area are acceptable only when they have a wider relevance to understanding human biological variation. Manuscripts may cover any of the following disciplines, once the anthropological focus is apparent: human population genetics, evolutionary and genetic demography, quantitative genetics, evolutionary biology, ancient DNA studies, biological diversity interpreted in terms of adaptation (biometry, physical anthropology), and interdisciplinary research linking biological and cultural diversity (inferred from linguistic variability, ethnological diversity, archaeological evidence, etc.).