Coronary microvascular disease: current concepts of pathophysiology, diagnosis and management.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2020-07-16 eCollection Date: 2021-03-01 DOI:10.1097/XCE.0000000000000223

Aish Sinha, Haseeb Rahman, Divaka Perera

引用次数: 0

Abstract

Coronary microvascular disease (CMD) is present in 30% of patients with angina and is associated with increased morbidity and mortality. We now have an improved understanding of the pathophysiology of CMD and the invasive and noninvasive tests that can be used to make the diagnosis. Recent studies have shown that management of CMD guided by physiological testing yields better results than empirical treatment. Despite major advances in diagnosing and stratifying this condition, therapeutic strategies remain limited and poorly defined. This review article discusses recent advances in understanding the pathophysiology of CMD, the modalities that are available to diagnose it clinically, current management options and a look at what is in store for the future.

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冠状动脉微血管疾病：病理生理学、诊断和管理的最新概念。

30%的心绞痛患者都患有冠状动脉微血管疾病（CMD），这种疾病会增加发病率和死亡率。目前，我们对冠心病的病理生理学以及用于诊断的有创和无创检测有了更深入的了解。最近的研究表明，以生理检测为指导的 CMD 治疗比经验性治疗效果更好。尽管在诊断和分层方面取得了重大进展，但治疗策略仍然有限且定义不清。这篇综述文章讨论了在了解慢性阻塞性肺病病理生理学方面的最新进展、临床诊断慢性阻塞性肺病的可用方法、当前的治疗方案以及对未来的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.