Meng Ye, Hang Jiang, Xianhui Fu, Jin-Rong Xu, Cong Jiang
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引用次数: 1
Abstract
The histone modifications usually form complicated networks to regulate accessibility of DNA and transcription. Identification of proteins that are involved in the crosstalk among different histone modifications will help to better understand the epigenetic regulatory network in eukaryotes. The Inhibitor of Growth (ING) proteins represent a tumor suppressor family were first linked to histone modification in yeast and their functions in epigenetic regulation were further characterized. This review summarizes the crosstalk of histone modification in fungi and describes recently achieved mechanistic insights into the role of Fng1 (an ING protein in filamentous ascomycetes) in this process. We conclude that Fng1 is involved in crosstalk among histone acetylation, deacetylation and methylation.
组蛋白修饰通常形成复杂的网络来调节DNA的可及性和转录。鉴定参与不同组蛋白修饰之间串扰的蛋白将有助于更好地理解真核生物的表观遗传调控网络。生长抑制蛋白(Inhibitor of Growth, ING)是一个肿瘤抑制蛋白家族，首次在酵母中与组蛋白修饰有关，并进一步表征了它们在表观遗传调控中的功能。本文综述了真菌中组蛋白修饰的串扰，并介绍了最近对Fng1(丝状子囊菌中的一种ING蛋白)在这一过程中的作用的机制见解。我们认为Fng1参与了组蛋白乙酰化、去乙酰化和甲基化之间的串扰。
期刊介绍：
Current Genetics publishes genetic, genomic, molecular and systems-level analysis of eukaryotic and prokaryotic microorganisms and cell organelles. All articles are peer-reviewed. The journal welcomes submissions employing any type of research approach, be it analytical (aiming at a better understanding), applied (aiming at practical applications), synthetic or theoretical.
Current Genetics no longer accepts manuscripts describing the genome sequence of mitochondria/chloroplast of a small number of species. Manuscripts covering sequence comparisons and analyses that include a large number of species will still be considered.
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