Impact of Negative Symptom Domains and Other Clinical Characteristics on Functional Outcomes in Patients with Schizophrenia.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2021-02-20 eCollection Date: 2021-01-01 DOI:10.1155/2021/8864352
Hiroki Okada, Dsisuke Hirano, Takamichi Taniguchi
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Abstract

Negative symptoms of schizophrenia have generally been defined using five factors; however, few studies have examined the relationship between these five factors and functional outcomes. In addition, there is no definitive conclusion regarding the association between negative symptoms and various aspects of functional outcomes (daily living, social, and vocational). This study is aimed at examining the relationship between these five domains of negative symptoms and different functional outcomes. Patients diagnosed with chronic schizophrenia (n = 100) were selected for the evaluation. We used the Brief Negative Symptom Scale to assess negative symptoms, the Brief Psychiatric Rating Scale to assess positive symptoms, the Schizophrenia Cognition Rating Scale to assess cognition, and the Evaluative Beliefs Scale (negative self-assessment) to assess psychological factors. We analyzed their relative impact on Social Functioning Scale domains using hierarchical multiple regression analysis. Concerning the relationship between daily living and negative symptoms, cognitive function showed the highest association with residential outcomes, such as self-care and shopping, while avolition appeared to show an additional contribution; however, for recreational outcomes, avolition showed the main association, whereas cognitive function showed no additional contribution. For social outcomes, asociality and negative self-assessment showed the main associations, while vocational outcomes were determined by both cognitive function and multiple negative symptoms, such as avolition, anhedonia, asociality, and alogia. Since negative symptom domains appear to differentially impact each outcome, specifically daily living outcome, it is important to evaluate the residential outcomes and recreational outcomes separately. Overall, the present study points to the importance of formulating psychosocial treatment strategies specific for each type of preferred outcome in patients with schizophrenia.

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消极症状领域和其他临床特征对精神分裂症患者功能结果的影响。
精神分裂症的阴性症状一般用五个因素来定义,但很少有研究对这五个因素与功能结果之间的关系进行研究。此外,关于阴性症状与各方面功能结果(日常生活、社交和职业)之间的关系也没有明确的结论。本研究旨在探讨阴性症状的这五个方面与不同功能结果之间的关系。我们选择了被诊断为慢性精神分裂症的患者(n = 100)进行评估。我们使用简明阴性症状量表来评估阴性症状,使用简明精神病评定量表来评估阳性症状,使用精神分裂症认知评定量表来评估认知,使用评价性信念量表(阴性自评)来评估心理因素。我们采用分层多元回归分析法分析了它们对社会功能量表各领域的相对影响。关于日常生活与消极症状之间的关系,认知功能与居住结果(如自理和购物)的关联度最高,而逃避似乎有额外的贡献;然而,对于娱乐结果,逃避显示了主要的关联,而认知功能没有显示额外的贡献。在社交结果方面,非社会性和消极的自我评估显示出主要的关联,而职业结果则取决于认知功能和多种消极症状,如逃避、失乐症、非社会性和焦虑症。由于阴性症状领域似乎对每种结果(尤其是日常生活结果)都有不同的影响,因此必须分别评估居住结果和娱乐结果。总之,本研究表明,针对精神分裂症患者偏好的每种治疗结果制定专门的心理社会治疗策略非常重要。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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