Dynamic Covalent Kinetic Resolution.

IF 9.3 2区 化学 Q1 CHEMISTRY, PHYSICAL Catalysis Reviews-Science and Engineering Pub Date : 2020-01-01 Epub Date: 2019-09-11 DOI:10.1080/01614940.2019.1664031
Yan Zhang, Yang Zhang, Olof Ramström
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引用次数: 10

Abstract

Implemented with the highly efficient concept of Dynamic Kinetic Resolution (DKR), dynamic covalent chemistry can be a useful strategy for the synthesis of enantioenriched compounds. This gives rise to dynamic covalent kinetic resolution (DCKR), a subset of DKR that over the last decades has emerged as increasingly fruitful, with many applications in asymmetric synthesis and catalysis. All DKR protocols are composed of two important parts: substrate racemization and asymmetric transformation, which can lead to yields of >50% with good enantiomeric excesses (ee) of the products. In DCKR systems, by utilizing reversible covalent reactions as the racemization strategy, the substrate enantiomers can be easily interconverted without the presence of any racemase or transition metal catalyst. Enzymes or other chiral catalysts can then be adopted for the resolution step, leading to products with high enantiopurities. This tutorial review focuses on the development of DCKR systems, based on different reversible reactions, and their applications in asymmetric synthesis.

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动态共价动力学分辨。
采用高效的动态动力学解析(DKR)概念,动态共价化学可以成为合成对映体富集化合物的有用策略。这就产生了动态共价动力学分解(DCKR),这是DKR的一个子集,在过去的几十年里已经越来越富有成果,在不对称合成和催化方面有许多应用。所有的DKR工艺都由两个重要的部分组成:底物外消旋化和不对称转化,这可以使产物的产率达到bbb50 %,并具有良好的对映体过量(ee)。在DCKR体系中,通过利用可逆共价反应作为外消旋策略,底物对映体可以很容易地相互转化,而不需要任何外消旋酶或过渡金属催化剂的存在。然后可以采用酶或其他手性催化剂进行分解步骤,从而得到具有高对映杂质的产品。本教程主要介绍了基于不同可逆反应的DCKR体系的发展及其在不对称合成中的应用。
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来源期刊
CiteScore
22.30
自引率
2.80%
发文量
29
期刊介绍: Catalysis Reviews is dedicated to fostering interdisciplinary perspectives in catalytic science and engineering, catering to a global audience of industrial and academic researchers. This journal serves as a bridge between the realms of heterogeneous, homogeneous, and bio-catalysis, providing a crucial and critical evaluation of the current state of catalytic science and engineering. Published topics encompass advances in technology and theory, engineering and chemical aspects of catalytic reactions, reactor design, computer models, analytical tools, and statistical evaluations.
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