Human papillomavirus E6 and E7: What remains?

IF 4.7 Q1 VIROLOGY Tumour Virus Research Pub Date : 2021-06-01 DOI:10.1016/j.tvr.2021.200213
Arushi Vats , Oscar Trejo-Cerro , Miranda Thomas, Lawrence Banks
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引用次数: 40

Abstract

Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us huge amounts of data on their expression, functions and structures. We know much about the very many cellular proteins and pathways that they influence in one way or another. However, much of this information is quite discrete, referring to one activity examined under one condition. It is now time to join the dots to try to understand a larger picture: how, where and when do all these interactions occur... and why? Examining these questions will also show how many of the yet obscure cellular processes work together for cellular and tissue homeostasis in health and disease.

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人乳头瘤病毒E6和E7:还剩下什么?
数十年来对人类乳头瘤病毒致癌基因E6和E7的研究为我们提供了大量关于它们的表达、功能和结构的数据。我们对许多细胞蛋白质和它们以这样或那样的方式影响的途径了解得很多。然而,这些信息大多是离散的,指的是在一种条件下检查的一项活动。现在是时候把这些点连起来,试图理解一个更大的图景:所有这些相互作用是如何、在哪里、何时发生的……,为什么?研究这些问题也将表明,在健康和疾病中,有多少尚不清楚的细胞过程共同作用于细胞和组织的稳态。
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来源期刊
Tumour Virus Research
Tumour Virus Research Medicine-Infectious Diseases
CiteScore
6.50
自引率
2.30%
发文量
16
审稿时长
56 days
期刊最新文献
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