Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis.

IF 3.2 Q1 OBSTETRICS & GYNECOLOGY Journal of Pregnancy Pub Date : 2021-03-05 eCollection Date: 2021-01-01 DOI:10.1155/2021/8870129
Leila Karimi, Somayeh Makvandi, Amir Vahedian-Azimi, Thozhukat Sathyapalan, Amirhossein Sahebkar
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Abstract

Background: Based on what is known at this time, pregnant women are at an increased risk of severe illness from COVID-19 compared to nonpregnant women. Additionally, pregnant women with COVID-19 might have an increased risk of adverse pregnancy outcomes. To investigate the effects of coronavirus disease 2019 (COVID-19) on mortality of pregnant and postpartum women, we performed a systematic review of available published literature on pregnancies affected by COVID-19.

Methods: Web of Science, SCOPUS, and MEDLINE- databases were searched for original studies concerning the effect of COVID-19 on mortality of pregnant and postpartum women published by July 10, 2020. Meta-analyses of proportions were used to combine data and report pooled proportions.

Results: 117 studies with a total of 11758 pregnant women were included. The age ranged between 15 and 48 years. Most subjects were infected with SARS-CoV-2 in the third trimester. Disease severity was not reported in 1125 subjects. Maternal mortality was 1.3%. In 100% of fatal cases with adequate data, fever alone or with cough was one of the presenting symptoms. Also, dyspnea (58.3%) and myalgia (50%) were the most common symptoms. Sore throat (8.3%) and gastrointestinal symptoms (anorexia, nausea) (8.3%) were rare. The rate of comorbidities was 20% among COVID-19 deaths. The majority of COVID-19-infected women who died had cesarean section (58.3%), 25% had a vaginal delivery, and 16.7% of patients were not full term.

Conclusion: COVID-19 infection in pregnant women was associated with higher rates (and pooled proportions) of cesarean section and mortality. Because new data are continuously being generated and published, the findings of this study can be complete and updated with new researches. The results of this study can guide and improve prenatal counseling of COVID-19-infected pregnant women.

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COVID-19对孕妇和产后妇女死亡率的影响:系统回顾和荟萃分析
背景:根据目前已知的情况,与非孕妇相比,孕妇患COVID-19严重疾病的风险更高。此外,感染COVID-19的孕妇出现不良妊娠结局的风险可能会增加。为了研究2019冠状病毒病(COVID-19)对孕妇和产后妇女死亡率的影响,我们对现有已发表的关于受COVID-19影响的妊娠的文献进行了系统回顾。方法:检索Web of Science、SCOPUS和MEDLINE数据库,检索截至2020年7月10日发表的关于COVID-19对孕妇和产后妇女死亡率影响的原始研究。比例的荟萃分析用于合并数据和报告合并比例。结果:纳入117项研究,共纳入11758名孕妇。年龄在15岁到48岁之间。大多数受试者在妊娠晚期感染SARS-CoV-2。1125名受试者未报告疾病严重程度。产妇死亡率为1.3%。在有充分资料的100%死亡病例中,单纯发烧或伴有咳嗽是主要症状之一。此外,呼吸困难(58.3%)和肌痛(50%)是最常见的症状。喉咙痛(8.3%)和胃肠道症状(厌食、恶心)(8.3%)罕见。在COVID-19死亡病例中,合并症发生率为20%。感染covid -19的死亡妇女中,大多数是剖腹产(58.3%),25%是阴道分娩,16.7%的患者没有足月分娩。结论:孕妇感染COVID-19与剖宫产率(及合并比例)和死亡率较高相关。由于新的数据不断产生和发表,本研究的结果可以通过新的研究来完善和更新。本研究结果可指导和完善新冠肺炎感染孕妇的产前咨询。
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来源期刊
Journal of Pregnancy
Journal of Pregnancy OBSTETRICS & GYNECOLOGY-
CiteScore
6.10
自引率
0.00%
发文量
15
审稿时长
14 weeks
期刊介绍: Journal of Pregnancy is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of pregnancy and childbirth. The journal welcomes submissions on breastfeeding, labor, maternal health and the biomedical aspects of pregnancy.
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