Infection with Hepatitis B Virus May Increase the Serum Concentrations of Osteopontin.

IF 3.2 4区医学 Q3 VIROLOGY Intervirology Pub Date : 2021-01-01 Epub Date: 2021-03-18 DOI:10.1159/000513687

Hua-Bing Liu, Qin-Yan Chen, Xue-Yan Wang, Lu-Juan Zhang, Li-Ping Hu, Tim J Harrison, Chao Wang, Zhong-Liao Fang

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引用次数: 4

Abstract

Background: Serum osteopontin (OPN) concentrations were found to be significantly increased in patients infected with hepatitis B virus (HBV) and patients with hepatocellular carcinoma (HCC).

Objective: The aim of this study was to determine the association among HCC, OPN, and HBV.

Methods: Two hundred and forty-one subjects were recruited and divided into 6 groups: healthy controls, asymptomatic HBsAg carriers, HBsAg (-) patients with other tumors, HBsAg (+) chronic liver disease patients, HBsAg (+) patients with HCC, and HBsAg (-) patients with HCC or liver cirrhosis (LC). Serum concentrations of OPN and HBsAg were measured and analyzed.

Results: OPN concentrations in the HBsAg (+) HCC group were significantly higher than the healthy control group and the HBsAg (-) patients with other cancers (both p = 0.0001). The OPN concentrations of the HBsAg (-) patients with HCC or LC also did not differ significantly from those of the healthy control group (p = 0.075). There is a correlation between the titer of HBsAg and concentrations of OPN in all 3 HBsAg (+) groups (all p values <0.05).

Conclusions: Infection with HBV may increase the serum concentrations of OPN. The association of OPN and HCC may be not attributable to tumor development per se but, rather, to HBV infection.

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乙型肝炎病毒感染可增加血清骨桥蛋白浓度。

背景：发现乙型肝炎病毒（HBV）感染者和肝细胞癌（HCC）患者血清骨桥蛋白（OPN）浓度显著升高。目的：本研究旨在确定HCC、OPN和HBV之间的相关性，无症状HBsAg携带者、其他肿瘤的HBsAg（-）患者、慢性肝病的HBsAg-（+）患者、HCC的HBsAg+患者以及HCC或肝硬化（LC）的HBsAg/-患者。测定并分析血清OPN和HBsAg的浓度。结果：HBsAg（+）HCC组的OPN浓度明显高于健康对照组和其他癌症的患者（均p=0.0001）3个HBsAg（+）组的OPN（均为p值）结论：HBV感染可增加血清OPN浓度。OPN与HCC的相关性可能不是肿瘤发展本身，而是HBV感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.