Recent Advancements in Engineering Strategies for Manipulating Neural Stem Cell Behavior.

Current tissue microenvironment reports Pub Date : 2020-06-01 Epub Date: 2020-04-03 DOI:10.1007/s43152-020-00003-y

Brian J O'Grady, Ethan S Lippmann

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引用次数: 1

Abstract

Purpose of review: Stem cells are exquisitely sensitive to biophysical and biochemical cues within the native microenvironment. This review focuses on emerging strategies to manipulate neural cell behavior using these influences in three-dimensional (3D) culture systems.

Recent findings: Traditional systems for neural cell differentiation typically produce heterogeneous populations with limited diversity rather than the complex, organized tissue structures observed in vivo. Advancements in developing engineering tools to direct neural cell fates can enable new applications in basic research, disease modeling, and regenerative medicine.

Summary: This review article highlights engineering strategies that facilitate controlled presentation of biophysical and biochemical cues to guide differentiation and impart desired phenotypes on neural cell populations. Specific highlighted examples include engineered biomaterials and microfluidic platforms for spatiotemporal control over the presentation of morphogen gradients.

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操纵神经干细胞行为的工程策略的最新进展。

综述目的:干细胞对原生微环境中的生物物理和生化信号非常敏感。这篇综述的重点是利用这些影响在三维(3D)培养系统中操纵神经细胞行为的新兴策略。最新发现:传统的神经细胞分化系统通常产生多样性有限的异质群体，而不是在体内观察到的复杂、有组织的组织结构。开发工程工具来指导神经细胞命运的进展可以在基础研究、疾病建模和再生医学中实现新的应用。摘要:这篇综述文章强调了促进生物物理和生化线索的受控呈现的工程策略，以指导神经细胞群体的分化和传递所需的表型。具体突出的例子包括工程生物材料和微流控平台，用于时空控制形态梯度的呈现。

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Current tissue microenvironment reports

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