Celastrol in metabolic diseases: Progress and application prospects

IF 10.5 2区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological research Pub Date : 2021-05-01 Epub Date: 2021-03-20 DOI:10.1016/j.phrs.2021.105572

Shaohua Xu , Yaqian Feng , Weishen He , Wen Xu , Wei Xu , Hongjun Yang , Xianyu Li

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引用次数: 45

Abstract

Metabolic diseases are becoming increasingly common in modern society. Therefore, it is essential to develop effective drugs or new treatments for metabolic diseases. As an active ingredient derived from plants, celastrol has shown great potential in the treatment of a wide variety of metabolic diseases and received considerable attention in recent years. In reported studies, the anti-obesity effect of celastrol resulted from regulating leptin sensitivity, energy metabolism, inflammation, lipid metabolism and even gut microbiota. Celastrol reversed insulin resistance via multiple routes to protect against type 2 diabetes. Celastrol also showed effects on atherosclerosis, cholestasis and osteoporosis. Celastrol in treating metabolic diseases seem to be versatile and the targets or pathways were diverse. Here, we systematically review the mechanism of action, and the therapeutic properties of celastrol in various metabolic diseases and complications. Based on this review, potential research strategies might contribute to the celastrol’s clinical application in the future.

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Celastrol在代谢性疾病中的研究进展及应用前景

代谢性疾病在现代社会变得越来越普遍。因此，开发有效的药物或新的治疗方法对代谢性疾病至关重要。作为一种从植物中提取的活性成分，雷公藤红素在多种代谢性疾病的治疗中显示出巨大的潜力，近年来受到了广泛的关注。在已有的研究中，celastrol的抗肥胖作用是通过调节瘦素敏感性、能量代谢、炎症、脂质代谢甚至肠道微生物群来实现的。雷公藤红素通过多种途径逆转胰岛素抵抗，预防2型糖尿病。雷公藤红素对动脉粥样硬化、胆汁淤积和骨质疏松也有影响。雷公藤红素在治疗代谢性疾病方面似乎是多功能的，其靶点或途径是多种多样的。在此，我们系统地综述了celastrol在各种代谢疾病和并发症中的作用机制和治疗特性。在此基础上，对雷公藤红素今后的临床应用提出了新的研究思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.