The MIGREX study: Prevalence and risk factors of sexual dysfunction among migraine patients

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY Neurologia Pub Date : 2023-10-01 DOI:10.1016/j.nrl.2021.02.006

M. Torres-Ferrus , A.C. López-Veloso , V. Gonzalez-Quintanilla , N. González-García , J. Díaz de Teran , A. Gago-Veiga , J. Camiña , M. Ruiz , N. Mas-Sala , S. Bohórquez , V.J. Gallardo , P. Pozo-Rosich

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引用次数: 1

Abstract

Background

Migraine attacks have a high impact on daily activities. There is limited research on the burden of migraine on sexual functioning.

Objective

To determine the prevalence of sexual dysfunction in patients with migraine and its relationship with migraine features and comorbidities.

Method

This is a cross-sectional study. We included migraine patients between 18 and 60 years-old from 8 Headache Clinics in Spain. We recorded demographic data and migraine features. Patients fulfilled a survey including comorbidities, Arizona Sexual Experiences Scale, Hospital Anxiety and Depression Scale and a questionnaire about migraine impact on sexual activity. A K-nearest neighbor supervised learning algorithm was used to identify differences between migraine patients with and without sexual dysfunction.

Results

We included 306 patients (85.6% women, mean age 42.3 ±11.1 years). A 41.8% of participants had sexual dysfunction. Sexual dysfunction was associated with being female (OR [95% CI]: 2.42 [1.17–5.00]; p < 0.001), being older than 46.5 years (4.04 [2.48–6.59]; p < 0.001), having chronic migraine (2.31 [1.41–3.77]; p = 0.001), using preventive medication (2.45 [1.35–4.45]; p = 0.004), analgesic overusing (3.51 [2.03–6.07]; p < 0.001), menopause (4.18 [2.43–7.17]; p < 0.001) and anxiety (2.90 [1.80–4.67]; p < 0.001) and depression (6.14 [3.18–11.83]; p < 0.001). However, only female gender, age, menopause and depression were the statistically significant variables selected in the model to classify migraine patients with or without sexual dysfunction (Accuracy [95% CI]: 0.75 (0.62–0.85), Kappa: 0.48, p = 0.005).

Conclusions

Sexual dysfunction is frequent in migraine patients visited in a headache clinic. However, migraine characteristics or use of preventive medication are not directly associated with sexual dysfunction. Instead, risk factors for sexual dysfunction were female gender, higher age, menopause and depression.

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MIGREX研究：偏头痛患者性功能障碍的患病率和危险因素

背景偏头痛发作对日常活动有很大影响。关于偏头痛对性功能负担的研究有限。目的确定偏头痛患者性功能障碍的患病率及其与偏头痛特征和合并症的关系。方法这是一项横断面研究。我们纳入了来自西班牙8家头痛诊所的18至60岁的偏头痛患者。我们记录了人口统计数据和偏头痛特征。患者完成了一项调查，包括合并症、亚利桑那州性经验量表、医院焦虑和抑郁量表以及一份关于偏头痛对性活动影响的问卷。使用K近邻监督学习算法来识别有性功能障碍和没有性功能障碍的偏头痛患者之间的差异。结果306例患者（女性85.6%，平均年龄42.3±11.1岁）。41.8%的参与者有性功能障碍。性功能障碍与女性（OR[95%CI]:2.42[1.17–5.00]；p<；0.001）、年龄超过46.5岁（4.04[2.48–6.59]；p<；001）、患有慢性偏头痛（2.31[1.41–3.77]；p=0.001）、使用预防性药物（2.45[1.35–4.45]；p=0.004）、过度使用止痛药（3.51[2.03–6.07]；p<；0.001）有关，更年期（4.18[2.43-7.17]；p<；0.001）、焦虑（2.90[1.80-4.67]；p&llt；0.001）和抑郁（6.14[3.18-11.83]；p&lgt；0.001）。然而，在该模型中，只有女性性别、年龄、更年期和抑郁是对有或无性功能障碍的偏头痛患者进行分类的统计学显著变量（准确度[95%CI]:0.75（0.62-0.85），Kappa:0.48，p=0.005）。结论性功能障碍在头痛门诊就诊的偏头痛患者中很常见。然而，偏头痛的特征或预防性药物的使用与性功能障碍没有直接关系。相反，性功能障碍的危险因素是女性、年龄较大、更年期和抑郁症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.