Environmental exposure to pesticides and Amyotrophic Lateral Sclerosis in the South of Spain

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY Neurologia Pub Date : 2023-09-01 DOI:10.1016/j.nrl.2021.01.013

S. Bermudo Fuenmayor , P.J. Serrano Castro , P. Quiroga Subirana , S. López Palmero , M. Requena Mullor , T. Parrón Carreño

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Abstract

Objective

To determine if there is a relationship between environmental exposure to pesticides and the prevalence of Amyotrophic Lateral Sclerosis (ALS) in Andalusia.

Method

We carried out a case–control study using the logistic regression method to verify the relationship between the prevalence of ALS in the area exposed to pesticides versus the unexposed area, through the Odds Ratio statistical test.

Results

The study population consisted of 519 individuals diagnosed with ALS between January 2016 and December 2018 according to the CMBD (Minimum Basic Data Set) as cases. In the control group, we have 8,384,083 individuals obtained from data from the National Institute of Statistics (INE). The Odds Ratio (OR) was used as a measure of association between cases and controls, obtaining an OR between 0.76 and 1.08 for the confidence interval of the CI (95%).

Conclusions

Despite the existence of various studies that suggest a possible association between environmental exposure to pesticides and the risk of Amyotrophic Lateral Sclerosis, our analysis of the Andalusian population did not find significant evidence of this association.

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西班牙南部农药环境暴露与肌萎缩侧索硬化症

目的确定环境农药暴露与安达卢西亚肌萎缩侧索硬化症（ALS）患病率之间是否存在关系。方法我们采用逻辑回归方法进行了一项病例对照研究，通过比值比统计检验来验证农药暴露地区与未暴露地区ALS患病率之间的关系。结果研究人群包括519名在2016年1月至2018年12月期间根据CMBD（最小基本数据集）诊断为ALS的患者。在对照组中，我们从国家统计研究所（INE）的数据中获得了8384083人。比值比（OR）被用作病例和对照之间相关性的衡量标准，CI的置信区间（95%）的OR在0.76和1.08之间。结论尽管存在各种研究表明环境暴露于杀虫剂与肌萎缩侧索硬化症风险之间可能存在关联，但我们对安达卢西亚人群的分析没有发现这种关联的重要证据。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.