Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults.

Joshua M Schrock, Daniel T Ryan, Rana Saber, Nanette Benbow, Lauren A Vaught, Nina Reiser, Matthew P Velez, Ryan Hsieh, Michael Newcomb, Alexis R Demonbreun, Brian Mustanski, Elizabeth M McNally, Richard D'Aquila, Thomas W McDade
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Abstract

Magnitude of SARS-CoV-2 virus exposure may contribute to symptom severity. In a sample of seropositive adults (n=1101), we found that individuals who lived with a known COVID-19 case exhibited greater symptom severity and IgG concentrations compared to individuals who were seropositive but did not live with a known case (P<0.0001).

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在以社区为基础的成人血清阳性样本中,家庭内暴露于SARS-CoV-2与更严重的症状和更强的抗体反应相关。
SARS-CoV-2病毒暴露程度可能与症状严重程度有关。在血清阳性成人样本(n=1101)中,我们发现与已知COVID-19病例生活在一起的个体比血清阳性但未与已知病例生活在一起的个体表现出更大的症状严重程度和IgG浓度(P
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