Immunogenicity of an intranasally administered modified live canine parvovirus type 2b vaccine in pups with maternally derived antibodies.

Vito Martella, Alessandra Cavalli, Nicola Decaro, Gabriella Elia, Costantina Desario, Marco Campolo, Giancarlo Bozzo, Elvira Tarsitano, Canio Buonavoglia
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引用次数: 66

Abstract

The ability of a modified live canine parvovirus type 2b vaccine to elicit active immunization in pups with maternally derived antibodies (MDA) by intranasal administration was evaluated. The vaccine induced seroconversion in 100% of pups with MDA titers of < or = 80 and in 51.6% of pups with titers between 160 and 320.

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经鼻给药改良犬细小病毒2b型活疫苗对母源抗体幼犬的免疫原性
研究了一种改良的犬细小病毒2b型活疫苗,通过鼻内给药诱导具有母源性抗体(MDA)的幼犬主动免疫的能力。在MDA滴度<或= 80的幼犬中,疫苗100%诱导血清转化,而在MDA滴度在160 - 320之间的幼犬中,疫苗的血清转化率为51.6%。
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