{"title":"Structure and mechanism of DNA polymerases.","authors":"Paul J Rothwell, Gabriel Waksman","doi":"10.1016/S0065-3233(04)71011-6","DOIUrl":null,"url":null,"abstract":"<p><p>DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All polymerases have a common architectural framework consisting of three canonical subdomains termed the fingers, palm, and thumb subdomains. Kinetically, they cycle through various states corresponding to conformational transitions, which may or may not generate force. In this review, we present and discuss the kinetic, structural, and single-molecule works that have contributed to our understanding of DNA polymerase function.</p>","PeriodicalId":51216,"journal":{"name":"Advances in Protein Chemistry","volume":"71 ","pages":"401-40"},"PeriodicalIF":0.0000,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0065-3233(04)71011-6","citationCount":"240","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Protein Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/S0065-3233(04)71011-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 240
Abstract
DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All polymerases have a common architectural framework consisting of three canonical subdomains termed the fingers, palm, and thumb subdomains. Kinetically, they cycle through various states corresponding to conformational transitions, which may or may not generate force. In this review, we present and discuss the kinetic, structural, and single-molecule works that have contributed to our understanding of DNA polymerase function.
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