Ultrastructural investigations on protective effects of NCX 4016 (nitroaspirin) on macrovascular endothelium in diabetic Wistar rats.

Journal of submicroscopic cytology and pathology Pub Date : 2005-08-01

M V Ambrosini, G Mariucci, M G Rambotti, M Tantucci, C Covarelli, L De Angelis, P Del Soldato

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Abstract

The effect of a nitric oxide-donating aspirin derivative, 2-acetoxy-benzoate 3-(nitroxy-methyl)phenyl ester (NCX 4016), and aspirin on the aortic endothelium of diabetic rats was investigated by using scanning and transmission electron microscopy. Control and streptozotocin-treated rats were used. Metabolic control was assessed by measuring blood and urine metabolites, and 24-h urine volume. The ultrastructural study was performed after 7 weeks of diabetes and 6 weeks of therapy. Streptozotocin treatment induced a persistent hyperglycemia which was not influenced by the pharmacological treatments. Values of blood metabolites were in line with the diabetic status. Both scanning and transmission electron microscopy revealed that aortic endothelium was severely damaged in all diabetic rats except for the NCX 4016 treated ones. Our data document the protective effects of NCX 4016 on the vascular endothelium of diabetic rats. Since aspirin had no protective action, NCX 4016 may have exerted its beneficial action by releasing nitric oxide.

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硝酸阿司匹林ncx4016对糖尿病大鼠大血管内皮保护作用的超微结构研究。

采用扫描电镜和透射电镜观察了一种一氧化氮给药阿司匹林衍生物、2-乙酰氧基苯甲酸3-(硝基甲基)苯基酯(ncx4016)和阿司匹林对糖尿病大鼠主动脉内皮的影响。对照组大鼠和链脲佐菌素处理大鼠。通过测定血、尿代谢物和24小时尿量来评估代谢控制。在糖尿病7周和治疗6周后进行超微结构研究。链脲佐菌素治疗引起持续性高血糖，不受药物治疗的影响。血液代谢物值与糖尿病状态一致。扫描电镜和透射电镜显示，除NCX 4016组外，所有糖尿病大鼠主动脉内皮均严重受损。我们的数据记录了ncx4016对糖尿病大鼠血管内皮的保护作用。由于阿司匹林没有保护作用，ncx4016可能通过释放一氧化氮发挥其有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of submicroscopic cytology and pathology

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