The role of MRS and fMRI in multiple sclerosis.

Advances in neurology Pub Date : 2006-01-01
Maria Carmela Tartaglia, Douglas L Arnold
{"title":"The role of MRS and fMRI in multiple sclerosis.","authors":"Maria Carmela Tartaglia,&nbsp;Douglas L Arnold","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Multiple sclerosis is now recognized as more than simply a disease of inflammation and demyelination in the brain and spinal cord. Conventional MRI has been established as the most important paraclinical tool in the diagnostic assessment of patients with suspected MS, and in the monitoring of treatment efficacy in clinical trials, at least in relapsing disease. Magnetization-transfer, diffusion-weighted MRI, 1H-MRS, and fMRI improve our ability to quantify the pathological changes in MS in vivo. Although we have gained some insight into the disease and are starting to uncover some of the structural and physiological substrates for the disability that develops in MS patients, we are far from understanding what causes MS and how to prevent its progression. Imaging can be used as a tool to better understand the pathophysiology of MS and ultimately improve on the treatment of MS.</p>","PeriodicalId":7356,"journal":{"name":"Advances in neurology","volume":"98 ","pages":"185-202"},"PeriodicalIF":0.0000,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in neurology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Multiple sclerosis is now recognized as more than simply a disease of inflammation and demyelination in the brain and spinal cord. Conventional MRI has been established as the most important paraclinical tool in the diagnostic assessment of patients with suspected MS, and in the monitoring of treatment efficacy in clinical trials, at least in relapsing disease. Magnetization-transfer, diffusion-weighted MRI, 1H-MRS, and fMRI improve our ability to quantify the pathological changes in MS in vivo. Although we have gained some insight into the disease and are starting to uncover some of the structural and physiological substrates for the disability that develops in MS patients, we are far from understanding what causes MS and how to prevent its progression. Imaging can be used as a tool to better understand the pathophysiology of MS and ultimately improve on the treatment of MS.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
MRS和fMRI在多发性硬化中的作用。
多发性硬化症现在被认为不仅仅是一种大脑和脊髓的炎症和脱髓鞘疾病。常规MRI已被确立为对疑似多发性硬化症患者进行诊断评估,以及在临床试验中监测治疗效果的最重要的临床辅助工具,至少在复发疾病中是如此。磁化转移、扩散加权MRI、1H-MRS和fMRI提高了我们在体内定量MS病理变化的能力。虽然我们已经对这种疾病有了一些了解,并开始揭示多发性硬化症患者残疾的一些结构和生理基础,但我们还远远不了解导致多发性硬化症的原因以及如何预防其进展。影像学可以作为一种工具,更好地了解MS的病理生理,最终提高MS的治疗水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
1
期刊最新文献
Historical overview. Paroxysmal choreoathetosis. Movement disorders. Inflammation in Parkinson's Disease 133a. Psychiatric outcome of epilepsy surgery
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1