Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle.

Francesca G Klinger, Natalia Battista, Massimo De Felici, Mauro Maccarrone
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引用次数: 12

Abstract

Recent studies have demonstrated that the endogenous cannabinoids are important modulators of fertility in mammals. In particular, a role of the endocannabinoid system in early stages of embryo development, oviductal transport of embryos, pregnancy maintenance and labour has been demonstrated in rodents and/or in humans. In the present paper, we report the analysis of FAAH activity and protein content in the mouse uterus as a function of the natural oestrus cycle stages. Variations of FAAH activity are discussed in relationship to changes in sex steroid levels and to the possible action of AEA on remodelling of uterine tissues.

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自然发情周期内小鼠子宫内黄豆酰胺水解酶活性的分期变化。
最近的研究表明,内源性大麻素是哺乳动物生育能力的重要调节剂。特别是,内源性大麻素系统在胚胎发育的早期阶段、胚胎的输卵管运输、妊娠维持和分娩中的作用已在啮齿动物和/或人类中得到证实。在本文中,我们报告了FAAH活性和蛋白质含量在小鼠子宫作为自然发情周期阶段的功能的分析。讨论了FAAH活性的变化与性类固醇水平的变化以及AEA对子宫组织重塑的可能作用的关系。
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