{"title":"The KA2 coupling reaction under green, solventless, heterogeneous catalysis","authors":"Giovanna Bosica, Roderick Abdilla","doi":"10.1016/j.molcata.2016.09.028","DOIUrl":null,"url":null,"abstract":"<div><p>Amberlyst A-21 supported CuI was found to be highly efficient novel heterogeneous catalyst for the three-component reaction between ketones, amines and alkynes, commonly called KA<sup>2</sup>-coupling. This inexpensive, easy-to-prepare, simple and recyclable catalyst has been employed in solventless conditions in the KA<sup>2</sup> coupling reaction involving both primary and secondary amines, ketones and various alkynes. The secondary and tertiary propargylamine products were obtained in good to excellent results in moderate reaction times.</p></div>","PeriodicalId":370,"journal":{"name":"Journal of Molecular Catalysis A: Chemical","volume":null,"pages":null},"PeriodicalIF":5.0620,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molcata.2016.09.028","citationCount":"31","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Catalysis A: Chemical","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1381116916304009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 31
Abstract
Amberlyst A-21 supported CuI was found to be highly efficient novel heterogeneous catalyst for the three-component reaction between ketones, amines and alkynes, commonly called KA2-coupling. This inexpensive, easy-to-prepare, simple and recyclable catalyst has been employed in solventless conditions in the KA2 coupling reaction involving both primary and secondary amines, ketones and various alkynes. The secondary and tertiary propargylamine products were obtained in good to excellent results in moderate reaction times.
期刊介绍：
The Journal of Molecular Catalysis A: Chemical publishes original, rigorous, and scholarly full papers that examine the molecular and atomic aspects of catalytic activation and reaction mechanisms in homogeneous catalysis, heterogeneous catalysis (including supported organometallic catalysis), and computational catalysis.
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