The role of virus-induced regulatory T cells in immunopathology.

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-07-14 DOI:10.1007/s00281-006-0019-2
Shelly J Robertson, Kim J Hasenkrug
{"title":"The role of virus-induced regulatory T cells in immunopathology.","authors":"Shelly J Robertson, Kim J Hasenkrug","doi":"10.1007/s00281-006-0019-2","DOIUrl":null,"url":null,"abstract":"<p><p>In recent years, regulatory T cells have received increased attention for their role in immune responses to microbial infections. The list of microbial pathogens associated with regulatory T cell responses is growing rapidly and includes bacteria, viruses, parasites, and fungi. As the biology of regulatory T cells is revealed, we are discovering that their induction during infection is a normal aspect of immunity, necessary to limit collateral damage from inflammatory responses and aggressive immunological effectors. Thus, these cells play a critical role in maintaining the delicate balance between preventing immunopathology and allowing the immune response to clear infections. While generally successful, there are notable exceptions where regulatory T cell-mediated suppression appears to be responsible for allowing certain viruses to establish and maintain a persistent state. In this review, we will discuss our current understanding of what virus-induced regulatory T cells are, how they are induced, and what mechanisms they use to suppress immunity. The complex role of Tregs in regulating immunity to viral infections, and the consequences their activity has on disease is illustrated by a review of specific viral infections including hepatitis C virus and human immunodeficiency virus.</p>","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 1","pages":"51-62"},"PeriodicalIF":0.0000,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079961/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Springer seminars in immunopathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00281-006-0019-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2006/7/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

In recent years, regulatory T cells have received increased attention for their role in immune responses to microbial infections. The list of microbial pathogens associated with regulatory T cell responses is growing rapidly and includes bacteria, viruses, parasites, and fungi. As the biology of regulatory T cells is revealed, we are discovering that their induction during infection is a normal aspect of immunity, necessary to limit collateral damage from inflammatory responses and aggressive immunological effectors. Thus, these cells play a critical role in maintaining the delicate balance between preventing immunopathology and allowing the immune response to clear infections. While generally successful, there are notable exceptions where regulatory T cell-mediated suppression appears to be responsible for allowing certain viruses to establish and maintain a persistent state. In this review, we will discuss our current understanding of what virus-induced regulatory T cells are, how they are induced, and what mechanisms they use to suppress immunity. The complex role of Tregs in regulating immunity to viral infections, and the consequences their activity has on disease is illustrated by a review of specific viral infections including hepatitis C virus and human immunodeficiency virus.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
病毒诱导的调节性 T 细胞在免疫病理学中的作用。
近年来,调节性 T 细胞因其在微生物感染免疫反应中的作用而受到越来越多的关注。与调节性 T 细胞反应相关的微生物病原体正在迅速增加,包括细菌、病毒、寄生虫和真菌。随着调节性 T 细胞生物学特性的揭示,我们发现在感染期间诱导调节性 T 细胞是免疫的一个正常方面,是限制炎症反应和侵袭性免疫效应物造成的附带损害所必需的。因此,这些细胞在维持预防免疫病理和允许免疫反应清除感染之间的微妙平衡方面发挥着至关重要的作用。虽然总体上是成功的,但也有明显的例外情况,即调节性 T 细胞介导的抑制似乎是导致某些病毒建立并维持持久状态的原因。在这篇综述中,我们将讨论我们目前对病毒诱导的调节性 T 细胞是什么、如何诱导以及它们抑制免疫的机制的理解。通过对丙型肝炎病毒和人类免疫缺陷病毒等特定病毒感染的综述,说明调节性 T 细胞在调节病毒感染免疫力方面的复杂作用及其活动对疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The discovery of immunostimulatory DNA sequence Cellular aspects of vasculitis — T cell-mediated aspects The complex role of Fcgamma receptors in the pathology of arthritis. IgA and IgA-specific receptors in human disease: structural and functional insights into pathogenesis and therapeutic potential. IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1