Yongxi Li , Guangwu Sun , Xihang He , Honggui Lv , Bing Gao
{"title":"Palladium-catalyzed intramolecular annulation of difluoroalkenes to difluoro- and trifluoromethylated indane analogs","authors":"Yongxi Li , Guangwu Sun , Xihang He , Honggui Lv , Bing Gao","doi":"10.1016/j.jfluchem.2023.110115","DOIUrl":null,"url":null,"abstract":"<div><p>An intramolecular annulation strategy has been developed for the synthesis of fluoroalkylated indane-type analogs. The difluoromethyl and trifluoromethyl functional motifs could be derived from <em>gem-</em>difluoroalkenes through this palladium-catalyzed reaction. This method is also extendable to other fluoroalkenes and multi-component reactions.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022113923000301","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
An intramolecular annulation strategy has been developed for the synthesis of fluoroalkylated indane-type analogs. The difluoromethyl and trifluoromethyl functional motifs could be derived from gem-difluoroalkenes through this palladium-catalyzed reaction. This method is also extendable to other fluoroalkenes and multi-component reactions.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.