Evaluation of association between polymorphism within the thyroglobulin gene and milk production traits in dairy cattle

IF 1.9 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal Breeding and Genetics Pub Date : 2007-02-12 DOI:10.1111/j.1439-0388.2007.00634.x

H. Khatib, I. Zaitoun, Y.M. Chang, C. Maltecca, P. Boettcher

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引用次数: 20

Abstract

In dairy cattle, many studies have reported quantitative trait loci (QTL) on the centromeric end of chromosome 14 that affect milk production traits. One of the candidate genes in this QTL region – thyroglobulin (TG) – was previously found to be significantly associated with marbling in beef cattle. Thus, based on QTL studies in dairy cattle and because of possible effects of this gene on fat metabolism, we investigated the association of TG with milk yield and composition in Holstein dairy cattle. A total of 1279 bulls from the Cooperative Dairy DNA Repository Holstein population were genotyped for a single nucleotide polymorphism in TG used previously in beef cattle studies. Analysis of 29 sire families showed no significant association between TG variants and milk production traits. Within-sire family analysis suggests that TG is neither the responsible gene nor a genetic marker in association with milk production traits.

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奶牛甲状腺球蛋白基因多态性与产奶量性状的相关性评价

在奶牛中，许多研究报道了位于14号染色体着丝粒端影响产奶量性状的数量性状位点(QTL)。该QTL区域的一个候选基因-甲状腺球蛋白(TG) -先前被发现与肉牛的大理石纹显著相关。因此，在奶牛QTL研究的基础上，考虑到该基因可能对脂肪代谢有影响，我们研究了TG与荷斯坦奶牛产奶量和组成的关系。对来自合作奶牛DNA库荷斯坦群体的1279头公牛进行了基因分型，分析了先前用于肉牛研究的甘油三酯单核苷酸多态性。29个父系的分析显示TG变异与产奶量性状无显著相关性。家族内分析表明，甘油三酯既不是负责基因，也不是与产奶性状相关的遗传标记。

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来源期刊

Journal of Animal Breeding and Genetics 农林科学-奶制品与动物科学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

12-24 weeks

期刊介绍： The Journal of Animal Breeding and Genetics publishes original articles by international scientists on genomic selection, and any other topic related to breeding programmes, selection, quantitative genetic, genomics, diversity and evolution of domestic animals. Researchers, teachers, and the animal breeding industry will find the reports of interest. Book reviews appear in many issues.